Publications

2024

Marco M, Jansen M, van der Weiden G, Reich E, Maatuf YH, Mastbergen SC, Dvir-Ginzberg M. "Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1."

Palmisano M, Ramunno CF, Farhat E, Dvir-Ginzberg M, Lutz B, de Almodovar CR, Bilkei-Gorzo A. "Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus."

Maatuf YH, Marco M, Unger-Gelman S, Farhat E, Zobrab A, Roy A, Kumar A, Carmon I, Reich E, Dvir-Ginzberg M. "Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice."

2023

Carmon I, Zobrab A, Alterman M, Tabib R, Cohen A, Kandel L, Greenberg A, Reich E, Casap N, Dvir-Ginzberg M. "Chondrocytes supplemented to bone graft-containing scaffolds expedite cranial defect repair."

Carmon I, Kalmus S, Zobrab A, Alterman M, Emram R, Gussarsky M, Kandel L, Reich E, Casap N, Dvir-Ginzberg M. "Repairing a critical cranial defect using WISP1-pretreated chondrocyte scaffolds."

2022

Carmon I, Smoum R, Farhat E, Reich E, Kandel L, Yekhtin Z, Gallily R, Mechoulam R, Dvir-Ginzberg M. "A Fenchone Derivative Effectively Abrogates Joint Damage Following Post-Traumatic Osteoarthritis in Lewis Rats."

Carmon I, Zecharyahu L, Elayyan J, Meka SRK, Reich E, Kandel L, Bilkei-Gorzo A, Zimmer A, Mechoulam R, Kravchenko-Balasha N, Dvir-Ginzberg M. "HU308 Mitigates Osteoarthritis by Stimulating Sox9-Related Networks of Carbohydrate Metabolism."

Elayyan J, Carmon I, Zecharyahu L, Batshon G, Maatuf YH, Reich E, Dumont M, Kandel L, Klutstein M, Dvir-Ginzberg M. "Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction."

Smith CA, Humphreys PA, Bates N, Naven MA, Cain SA, Dvir-Ginzberg M, Kimber SJ. "SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation."

2021

Meka SRK, Younis T, Reich E, Elayyan J, Kumar A, Merquiol E, Blum G, Kalmus S, Maatuf YH, Batshon G, Nussbaum G, Houri-Haddad Y, Dvir-Ginzberg M. "TNFα expression by Porphyromonas gingivalis-stimulated macrophages relies on Sirt1 cleavage."

2020

Bernotiene E, Bagdonas E, Kirdaite G, Bernotas P, Kalvaityte U, Uzieliene I, Thudium CS, Hannula H, Lorite GS, Dvir-Ginzberg M, Guermazi A, Mobasheri A. "Emerging Technologies and Platforms for the Immunodetection of Multiple Biochemical Markers in Osteoarthritis Research and Therapy."

Batshon G, Elayyan J, Qiq O, Reich E, Ben-Aderet L, Kandel L, Haze A, Steinmeyer J, Lefebvre V, Zhang H, Elisseeff J, Henrotin Y, Mobasheri A, Dvir-Ginzberg M. "Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence."

Bulvik R, Breuer R, Dvir-Ginzberg M, Reich E, Berkman N, Wallach-Dayan SB. "SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis."

2018

Kumar A, Daitsh Y, Ben-Aderet L, Qiq O, Elayyan J, Batshon G, Reich E, Maatuf YH, Engel S, Dvir-Ginzberg M. "A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage."

2017

Bilkei-Gorzo A, Albayram O, Draffehn A, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Rácz I, Ulas T, Imbeault S, Bab I, Schultze JL, Zimmer A. "A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice."

Elayyan J, Lee EJ, Gabay O, Smith CA, Qiq O, Reich E, Mobasheri A, Henrotin Y, Kimber SJ, Dvir-Ginzberg M. "LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes."

Sanchez C, Bay-Jensen AC, Pap T, Dvir-Ginzberg M, Quasnichka H, Barrett-Jolley R, Mobasheri A, Henrotin Y. "Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis."

Lefebvre V, Dvir-Ginzberg M. "SOX9 and the many facets of its regulation in the chondrocyte lineage."

2016

Dvir-Ginzberg M, Mobasheri A, Kumar A. "Erratum to: The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis."

Dvir-Ginzberg M, Mobasheri A, Kumar A. "The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis."

Bar Oz M, Kumar A, Elayyan J, Reich E, Binyamin M, Kandel L, Liebergall M, Steinmeyer J, Lefebvre V, Dvir-Ginzberg M. "Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes."

2015

Ben-Aderet L, Merquiol E, Fahham D, Kumar A, Reich E, Ben-Nun Y, Kandel L, Haze A, Liebergall M, Kosińska MK, Steinmeyer J, Turk B, Blum G, Dvir-Ginzberg M. "Detecting cathepsin activity in human osteoarthritis via activity-based probes."

2014

Dvir-Ginzberg M, Reich E. "Chopping off the chondrocyte proteome."

Oppenheimer H, Kumar A, Meir H, Schwartz I, Zini A, Haze A, Kandel L, Mattan Y, Liebergall M, Dvir-Ginzberg M. "Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation."

2013

Gabay O, Zaal KJ, Sanchez C, Dvir-Ginzberg M, Gagarina V, Song Y, He XH, McBurney MW. "Sirt1-deficient mice exhibit an altered cartilage phenotype."

Gabay O, Sanchez C, Dvir-Ginzberg M, Gagarina V, Zaal KJ, Song Y, He XH, McBurney MW. "Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model."

Dvir-Ginzberg M, Steinmeyer J. "Towards elucidating the role of SirT1 in osteoarthritis."

2012

Gabay O, Oppenhiemer H, Meir H, Zaal K, Sanchez C, Dvir-Ginzberg M. "Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice."

Oppenheimer H, Gabay O, Meir H, Haze A, Kandel L, Liebergall M, Gagarina V, Lee EJ, Dvir-Ginzberg M. "75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes."

2011

Dvir-Ginzberg M, Gagarina V, Lee EJ, Booth R, Gabay O, Hall DJ. "Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes."

Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. "CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts."

2010

Yaniv A, Neumann Y, David R, Stiubea-Cohen R, Orbach Y, Lang S, Rotter N, Dvir-Ginzberg M, Aframian DJ, Palmon A. "Establishment of immortal multipotent rat salivary progenitor cell line toward salivary gland regeneration."

Gagarina V, Gabay O, Dvir-Ginzberg M, Lee EJ, Brady JK, Quon MJ, Hall DJ. "SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway."

2008

Dvir-Ginzberg M, Gagarina V, Lee EJ, Hall DJ. "Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase."

Dvir-Ginzberg M, Elkayam T, Cohen S. "Induced differentiation and maturation of newborn liver cells into functional hepatic tissue in macroporous alginate scaffolds."