Skeletal mobility is largely dependent on the function of our joints. The thin hyaline cartilage layer covering our bones form cushions that allow us to comfortably perform all types of physical activities. Aside from these functions, healthy cartilage protects bones from erosion, by functioning as a shock absorber during moderate or intense activity. Our lab is exploring the myriad roles of Sirtuins in Cartilage biology, during aging, fracture, trauma and skeletal development.

 

Based on accumulated mechanistic insight, our lab is exploring potential compounds and drugs, to delay joint diseases with a particular focus on osteoarthritis. Simultaneous research efforts are recently under way in our lab with a particular aim to utilize novel biomarkers for the stratification of disease severity, to ultimately support personalized treatment for numerous skeletal conditions, including osteoarthritis.